Monkey models, techniques, and associated services include:

• Models: Cellular transfer (autologous, allogeneic, xenogeneic), direct gene delivery (systemic and organ-targeting)
• Ultrasound-related techniques: Diagnostic imaging including growth and biometrics; biophysical profiles; pulsed and color Doppler; echocardiography; ultrasound-guided sample collection including: placental biopsy, amniocentesis, fetal blood samples, tissue biopsy (fetus to adult)
• Postnatal studies: Simian Apgar scores, neurobehavioral test batteries, growth and maturation, bone marrow aspirates/biopsies, liver biopsies, liver and lung function tests, cardiovascular assessments
• In vivo imaging: Ultrasound, microPET, optical imaging
• Laboratory services: Processing and cryopreservation of specimens including cell suspensions, cell and tissue culture, PCR and RT-PCR, ELISA (i.e., cytokines, antibody responses), lymphocyte proliferation assays, tissue embedding, sectioning, and staining, immunohistochemistry, in situ hybridization, microscopy, morphometry, laser capture microdissection
• Tissue harvests: Complete tissue collection, processing, and analyses
• Flow cytometry/immunophenotyping and cell selection: blood, marrow, cell suspensions, monkey-specific antibodies
• Consultation for protocol development and design

Technology Development

A wide range of new gene transfer-related techniques and procedures are routinely developed each year. As investigators discuss their respective research projects, it is anticipated that new techniques will be developed, and that additional services will become available. Any new techniques developed through our research efforts including our work with stem and progenitor cell populations and molecular assays, will be made available to investigators.